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Promega
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BOC Sciences
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Destiny Pharma
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COMSOL Inc
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Image Search Results
Journal: PLoS ONE
Article Title: Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies
doi: 10.1371/journal.pone.0145409
Figure Lengend Snippet: BOC, boceprevir; MCB, mericitabine; P/R, peginterferon alfa-2a + ribavirin.
Article Snippet: Patients randomized to Arm C received 4 weeks of
Techniques:
Journal: PLoS ONE
Article Title: Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies
doi: 10.1371/journal.pone.0145409
Figure Lengend Snippet: MCB, mericitabine; P/R, peginterferon alfa-2a + ribavirin; TVR, telaprevir.
Article Snippet: Patients randomized to Arm C received 4 weeks of
Techniques:
Journal: PLoS ONE
Article Title: Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies
doi: 10.1371/journal.pone.0145409
Figure Lengend Snippet: BOC, boceprevir 800 mg TID (at recommended intervals of 7–9 hours); MCB, mericitabine 1000 mg BID; P/R, peginterferon alfa-2a 180 μg once/week + ribavirin 1000 mg/day (<75 kg) or 1200 mg/day (≥75 kg); PBO, placebo; TVR, telaprevir 750 mg TID (at recommended intervals of 7–9 hours). Control Arms C in DYNAMO 1 and D in DYNAMO 2 were closed due to futility while the studies were ongoing (27 July 2012 in DYNAMO 1 and 10 July 2012 in DYNAMO 2), after which patients in these groups were given the option to receive mericitabine for a maximum duration of 24 weeks. MCB was added to the regimen for 5 patients in Arm C in DYNAMO 1 and to the regimen for 9 patients in Arm D in DYNAMO 2 at various time points and for various durations.
Article Snippet: Patients randomized to Arm C received 4 weeks of
Techniques:
Journal: PLoS ONE
Article Title: Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies
doi: 10.1371/journal.pone.0145409
Figure Lengend Snippet: Baseline characteristics (all randomized patients). BOC, boceprevir; MCB, mericitabine; P/R, peginterferon alfa-2a/ribavirin; TVR, telaprevir
Article Snippet: Patients randomized to Arm C received 4 weeks of
Techniques:
Journal: PLoS ONE
Article Title: Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies
doi: 10.1371/journal.pone.0145409
Figure Lengend Snippet: BOC, boceprevir; MCB, mericitabine; P/R, peginterferon alfa-2a + ribavirin; TVR, telaprevir.
Article Snippet: Patients randomized to Arm C received 4 weeks of
Techniques:
Journal: PLoS ONE
Article Title: Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies
doi: 10.1371/journal.pone.0145409
Figure Lengend Snippet: Virological response at end of treatment and at week 4, 12 and 24 of follow-up (all treated patients) and relapse at week 4, 12 and 24 of follow-up. BOC, boceprevir; CI, 95% confidence interval; MCB, mericitabine; P/R, peginterferon alfa-2a/ribavirin; TVR, telaprevir
Article Snippet: Patients randomized to Arm C received 4 weeks of
Techniques:
Journal: PLoS ONE
Article Title: Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies
doi: 10.1371/journal.pone.0145409
Figure Lengend Snippet: Adverse events and laboratory abnormalities. ALT, alanine transaminase; BOC, boceprevir; MCB, mericitabine; P/R, peginterferon alfa-2a/ribavirin; TVR, telaprevir; ULN, upper limit of normal
Article Snippet: Patients randomized to Arm C received 4 weeks of
Techniques: